Endocrine Abstracts

Introduction: We submit a rare presentation of primary hyperparathyroidism in pregnancy posing complex management difficulties.Case report: A 32-year-old Asian woman presented during third trimester of her pregnancy with symptoms of lethargy, leg pain, and weakness. Routine investigations revealed an elevated calcium level (3.83 mM) and PTH level of 231.1 ng/l. She was treated with i.v. fluids and pamidronate. An ultrasound of her thyroid gland showed a ...

Background: Premature ovarian failure is not uncommon in patients with polyglandular autoimmune conditions. It is rare for patients to become pregnant beyond the menopause. We present a patient with premature ovarian failure who spontaneously conceived after attaining menopausal state.Case: We had a 41-year-old Asian lady with type1 diabetes mellitus since 30 years of age. She had widespread vitiligo, strongly positive thyroid microsomal antibody and a f...

Introduction: Hypothalamic–pituitary adrenal axis dysfunction is common in severely ill patients. Even slight impairment of adrenal response to severe illness can increase morbidity and mortality. Relative adrenal insufficiency has been associated with severe sepsis.Case report: We report a case of 48-year-old lady who was admitted with septic shock secondary to epiglottitis requiring intubation and intensive care. Short synacthen test performed in ...

Background: Autoimmune Graves’ disease is the most common cause of hyperthyroidism. Medical management of Graves’ thyrotoxicosis with thionamides is complicated by a reported relapse rate of about 60%.Aims: The aims of this study were to determine the relapse rate of patients treated with drugs as first line treatment for Graves’ disease and to assess the impact of patient demographics, serum free T4(fT4) and clinical characteristics on re...

Introduction: Maternal hypothyroidism is the most common disorder of thyroid function in pregnancy and may influence the outcome of mother and fetus at all stages.Aim: To evaluate screening and management of all high risk pregnant women for thyroid dysfunction.Method: A retrospective audit as carried out between January 2005 and December 2006. Our local standards were TSH<3 mIU/l for screening and TSH<2 mIU/l for treatment....